Fresh analysis indicates that individuals who stop using popular slimming jabs like Mounjaro or Wegovy can put back on shed pounds far faster than those who halt conventional diet and exercise regimens.
Findings released in a leading medical journal points out that while obese people can lose about a fifth of their body weight while undergoing treatment, the mass returns at an estimated rate of nearly a kilo each month once they quit.
"Individuals purchasing such medications need to be cognizant of the danger of quick rebound weight gain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
That rate of regain means a return to pre-treatment weight in about 18 months.
Analyzing Treatments
The research, which looked at 37 of studies involving thousands of participants, compared the effects of the injectable medications with conventional dieting.
Scientists point out that people who shed pounds through lifestyle changes alone usually experience a more gradual weight regain—approximately 0.1 kg a month—post-intervention.
Explaining the Quick Regain
Experts believe the way of the injections explains the amplified rebound.
GLP-1 drugs copy a body's own chemical called GLP-1, which moderates feelings of fullness.
"Long-term administration of GLP-1 levels far above than the body's typical production may cause the system to produce less of its own natural GLP-1, and may also reduce sensitivity to its effects," explained Dr. Adam Collins, a nutrition expert.
"Withdrawal of this medication means appetite is uncontrolled, making binge eating a significant risk."
A Chronic Disease?
Medical guidelines suggest the injections for people with obesity-related health risks, accompanied by prescribed lifestyle changes.
A number of clinicians contend that, given the high risk of relapse, the treatment might need to be life-long.
This opinion is reinforced by pharmaceutical companies, who state that the results "highlight the long-term character of obesity," comparing it to managing conditions like hypertension.
Patient Experiences
Individuals who have come off the medication report a intense return of appetite.
"It felt as if a trigger flipping and you become ravenous," described an individual.
The struggle is worsened if individuals have not established sustainable dietary or behavioural modifications during therapy.
Widespread Adoption
Survey data indicate that a significant number of people in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Adoption is more common among women than men.
- The 40s and 50s demographic shows the greatest level of interest.
- Many obtain the medications through private healthcare rather than public health services.
Ultimately, experts stress that while these medications are potent tools for weight loss, they are not a permanent fix and maintained weight loss hinges on ongoing behavioural support.
